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Catalytic Promiscuity of cGAS: A Facile Enzymatic Synthesis of 2′‐3′‐Linked Cyclic Dinucleotides
3JH,H=8.6 Hz, 4.3 Hz, 1H; CH), 5.06 (d, J=7.4 Hz, 1H; CH), 4.72 (d, J=5.'6 Hz, 1H; CH), 4.62 (d, J=4.3 Hz, 1H; CH), 4.44 (d, J= 2.4 Hz, 1H; CH), 4.38 (s, 1H; CH), 4.27 (m, 2H; CH2), 4.37, 4.14 ppm (m, 2H; [...] 1H; CH), 5.67 (dt, 3JH,H=8.2 Hz, 4.3 Hz, 1H; CH), 5.56 (m, 1H; CH), 5.12 (m, 1H; CH), 4.60 (d, J=4.3 Hz, 1H; CH), 4.57 (m, 1H; CH), 4.40 (m, 1H; CH), 4.25 (m, 2H; CH2), 4.16 ppm (m, 2H; CH2);
13C NMR (600 [...] carried out. Thus, 10 μmol of the substrates (5.8 mg 2’-F-ATP, 5.8 mg 8- Br-ATP, 5.4 mg 8-Cl-ATP, 5.2 mg 8-NH2-ATP, or 5.4 mg 8-N3-ATP and 5.2 mg GTP) were converted into the corresponding cyclic dinucleotide …
